Neuroblastoma vs Wilms : FRCR Paediatrics

Neuroblastoma vs Wilms  

These two pathologies are popular topics on the FRCR 2A and 2B exams. The comparison below aims to help candidates distinguish between the two by explaining the key characteristics of each disease. This is particularly important to know for the SBA/MCQ questions

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Neuroblastoma 

Age: Less than 2 

Location: Adrenals (70%), Thorax (20%), Neck (5%) 

Associated with Beckwith–Wiedemann, NF 1, DiGeorge syndrome, Hirschsprung disease 

Calcification in 90% 

Encases the vessels / Elevation of the aorta  

Crosses the midline  

Extension into the spinal canal via the neural foramina 

Metastases to the bone (60%), lymph nodes (42%) and intracranial (15%) 

Wilms 

3^rd most common cause of a renal mass (hydronephrosis multicystic dysplastic kidney are ...